Development of Experimental Oil based Inactivated HS Vaccine from field Isolates of Pasteurella multocida from Cattle in Bangladesh

Hemorrhagic septicemia is an economically important bacterial disease of cattle and buffaloes [6]. The disease remains a significant obstacle to sustainable livestock production in most parts of tropical Asia and Africa. It is caused by Pasteurella multocida a natural inhabitant of the mucosal surfaces of upper part of the respiratory tract of ruminants, and under predisposing environmental or management conditions which constitute stress for the animals such as transport (shipping fever), marketing, change of feed, climate or ventilation [1]. The disease is per acute, having a short clinical course, involving severe depression, pyrexia, submandibular edema, and dyspnea, followed by recumbency and responsible for 70% above bovine mortality [2].